On a chemical level, Indica and Sativa strains are different in their composition of the cannabinoid content, as well as in the balance of other compounds, such as terpenes and flavonoids.

Sativa strains usually show a high THC content and low CBD content, while indica strains tend have a lower THC content, and a somewhat higher CBD content.

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Today, thanks to current breeding techniques, both Indica and Sativa strains can be found with varying THC/CBD cannabinoid concentrations.

Because sativa strains may cause feelings of alertness and optimism, many patients prefer to medicate with this type of cannabis during the day.